Your browser doesn't support javascript.
loading
Characterization of Japanese multiple sclerosis patients with progression independent of relapse activity: A 2-year multicenter cohort study.
Yokote, Hiroaki; Miyazaki, Yusei; Fujimori, Juichi; Nishida, Yoichiro; Toru, Shuta; Niino, Masaaki; Nakashima, Ichiro; Miura, Yoshiharu; Yokota, Takanori.
Affiliation
  • Yokote H; Department of Neurology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan; Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address: yktenuro@tmd.ac.jp.
  • Miyazaki Y; Department of Clinical Research, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
  • Fujimori J; Division of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
  • Nishida Y; Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan.
  • Toru S; Department of Neurology, Nitobe Memorial Nakano General Hospital, Tokyo, Japan.
  • Niino M; Department of Clinical Research, National Hospital Organization Hokkaido Medical Center, Sapporo, Japan.
  • Nakashima I; Division of Neurology, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
  • Miura Y; Department of Neurology, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
  • Yokota T; Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan.
J Neuroimmunol ; 394: 578407, 2024 09 15.
Article in En | MEDLINE | ID: mdl-39068747
ABSTRACT
Progression independent of relapse activity (PIRA) is prevalent among Caucasian patients with relapsing and remitting multiple sclerosis (RRMS). However, there is limited knowledge regarding the characteristics of PIRA in Asian patients with RRMS. Therefore, we retrospectively analyzed the clinical and radiological progression of 95 Japanese patients with RRMS during a 2-year observation period. PIRA was observed in three patients who were characterized by young age, large T2 lesion volume, and great reduction in brain volume. Despite having highly active disease, fewer patients with PIRA (33.3%) were treated with high-efficacy drugs compared with those without disease activity (60.7%).
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Disease Progression / Multiple Sclerosis, Relapsing-Remitting Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Neuroimmunol / J. neuroimmunol / Journal of neuroimmunology Year: 2024 Document type: Article Country of publication: Países Bajos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Disease Progression / Multiple Sclerosis, Relapsing-Remitting Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Neuroimmunol / J. neuroimmunol / Journal of neuroimmunology Year: 2024 Document type: Article Country of publication: Países Bajos