Covalent Organic Framework-Based Theranostic Platforms for Restricting H1N1 Influenza Virus Infection.
Int J Nanomedicine
; 19: 7399-7414, 2024.
Article
in En
| MEDLINE
| ID: mdl-39071500
ABSTRACT
Background:
Influenza A (H1N1) virus is a highly contagious respiratory disease that causes severe illness and death. Vaccines and antiviral drugs are limited by viral variation and drug resistance, so developing efficient integrated theranostic options appears significant in anti-influenza virus infection.Methods:
In this study, we designed and fabricated covalent organic framework (COF) based theranostic platforms (T705@DATA-COF-Pro), which was composed of an RNA polymerase inhibitor (favipiravir, T705), the carboxyl-enriched COF (DATA-COF) nano-carrier and Cy3-labeled single DNA (ssDNA) probe.Results:
The multi-porosity COF core provided an excellent micro-environment and smooth delivery for T705. The ssDNA probe coating bound to the nucleic acids of H1N1 selectively, thus controlling drug release and allowing fluorescence imaging. The combination of COF and probe triggered the synergism, promoting drug further therapeutic outcomes. With the aid of T705@DATA-COF-Pro platforms, the H1N1-infected mouse models lightly achieved diagnosis and significantly prolonged survival.Conclusion:
This research underscores the distinctive benefits and immense potential of COF materials in nano-preparations for virus infection, offering novel avenues for the detection and treatment of H1N1 virus infection.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antiviral Agents
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Orthomyxoviridae Infections
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Influenza A Virus, H1N1 Subtype
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Theranostic Nanomedicine
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Metal-Organic Frameworks
Limits:
Animals
/
Humans
Language:
En
Journal:
Int J Nanomedicine
/
Int. j. nanomed. (Online)
/
International journal of nanomedicine (Online)
Year:
2024
Document type:
Article
Country of publication:
Nueva Zelanda