Efficient Study Design and Analysis of Longitudinal Dose-Response Data Using Fractional Polynomials. | Pharm Stat;2024 Jul 28. | MEDLINE

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Efficient Study Design and Analysis of Longitudinal Dose-Response Data Using Fractional Polynomials.

Hartley, Benjamin F; Lunn, Dave; Mander, Adrian P.

Affiliation

Hartley BF; Veramed Ltd., Twickenham, UK.
Lunn D; Department of Biostatistics, GSK Research and Development, Brentford, UK.
Mander AP; Department of Biostatistics, GSK Research and Development, Brentford, UK.

Pharm Stat ; 2024 Jul 28.

Article in En | MEDLINE | ID: mdl-39073285

Key words

Cefficiency; Defficiency; Emax model; Fisher information matrix; clinical trial design; interim analysis; longitudinal modelling; minimum effective dose

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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pharm Stat Journal subject: FARMACOLOGIA Year: 2024 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Pharm Stat Journal subject: FARMACOLOGIA Year: 2024 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido