Noradrenergic alterations associated with early life stress.
Neurosci Biobehav Rev
; 164: 105832, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39084582
ABSTRACT
Significant stress in childhood or adolescence is linked to both structural and functional changes in the brain in human and analogous animal models. In addition, neuromodulators, such as noradrenaline (NA), show life-long alterations in response to these early life stressors, which may impact upon the sensitivity and time course of key adrenergic activities, such as rapid autonomic stress responses (the 'fight or flight response'). The locus-coeruleus noradrenergic (LC-NA) network, a key stress-responsive network in the brain, displays numerous changes in response to significant early- life stress. Here, we review the relationship between NA and the neurobiological changes associated with early life stress and set out future lines of research that can illuminate how brain circuits and circulating neurotransmitters adapt in response to childhood stressors.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stress, Psychological
/
Norepinephrine
Limits:
Animals
/
Humans
Language:
En
Journal:
Neurosci Biobehav Rev
Year:
2024
Document type:
Article