HLA alleles associated to susceptibility to gliptin-associated bullous pemphigoid in Italian patients.
HLA
; 104(2): e15616, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-39091267
ABSTRACT
Bullous pemphigoid (BP), although a rare disease, is the most frequent subepidermal autoimmune disorder. Treatment with gliptins, used for type 2 diabetes, was reported as associated with BP onset. To identify HLA alleles that may reflect a higher susceptibility to BP in the Italian population, we analysed 30 patients affected by idiopathic bullous pemphigoid (IBP) and 86 gliptin-associated BP (GABP) patients. A significant association between HLA-DQB1*0301 allele and IBP and GABP patients was found. Of note, both IBP and GABP were significantly associated with one of the following haplotypes DRB1*1101, DRB3*0202, DQA1*0505, DQB1*0301 or DRB1*1104, DRB3*0202, DQA1*0505 and DQB1*0301. These data identify, for the first time, potential markers of susceptibility to BP in the Italian population, especially when associated with gliptin intake.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Haplotypes
/
Pemphigoid, Bullous
/
Genetic Predisposition to Disease
/
Alleles
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
En
Journal:
HLA
Year:
2024
Document type:
Article
Affiliation country:
Italia
Country of publication:
Reino Unido