Protein Kinase A Inhibitor Attenuates the Antinociceptive Effect of NMDA-Receptor Channel Antagonists in the Capsaicin Test in Mice.
Bull Exp Biol Med
; 177(2): 231-234, 2024 Jun.
Article
in En
| MEDLINE
| ID: mdl-39093477
ABSTRACT
Acute nociceptive pain in mice caused by subcutaneous (intraplantar) injection of TRPV1 ion channel agonist capsaicin (1.6 µg/mouse) and the effects of protein kinase A inhibitor H-89 (0.05 mg/mouse, intraplantar injection) and NMDA receptor channel antagonists MK-801 (7.5 and 15 µg/mouse, topical application) and hemantane (0.5 mg/mouse, topical application) on the pain were assessed. MK-801 and hemantane were found to reduce the duration of the pain response. H-89 did not significantly affect the pain in animals, but preliminary administration of this drug abolished the antinociceptive effect of MK-801 (7.5 µg/mouse) and weakens the effect of hemantane (0.5 mg/mouse).
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Capsaicin
/
Dizocilpine Maleate
/
Receptors, N-Methyl-D-Aspartate
/
Analgesics
Limits:
Animals
Language:
En
Journal:
Bull Exp Biol Med
Year:
2024
Document type:
Article
Affiliation country:
Rusia
Country of publication:
Estados Unidos