Anticoagulant therapy in renal insufficiency theme: Anticoagulation in complex situations.
Thromb Res
; 241: 109097, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39094333
ABSTRACT
Many patients with impaired renal function have concurrent indications for anticoagulant therapy, including atrial fibrillation and venous thromboembolism. For mild chronic kidney disease, data from clinical trials and existing guidelines can be applied to clinical management. The benefits and harms of anticoagulation therapy in patients with more advanced renal impairment are nuanced, as both thrombotic and bleeding risk are increased. Until recently, data regarding anticoagulants in severe renal impairment were primarily observational, but emerging evidence includes a few small clinical trials and the emergence of novel agents hypothesized to have improved efficacy and safety in this population. In this review, we summarize existing data on anticoagulation in patients with chronic kidney disease. We suggest a framework for anticoagulation decision-making in the burgeoning worldwide population of patients with chronic kidney disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anticoagulants
Limits:
Humans
Language:
En
Journal:
Thromb Res
/
Thromb. res
/
Thrombosis research
Year:
2024
Document type:
Article
Country of publication:
Estados Unidos