Insights into bacterial metabolism from small RNAs.
Cell Chem Biol
; 31(9): 1571-1577, 2024 Sep 19.
Article
in En
| MEDLINE
| ID: mdl-39094580
ABSTRACT
The study of small, regulatory RNAs (sRNA) that act by base-pairing with target RNAs in bacteria has been steadily advancing, particularly with the availability of more and more transcriptome and RNA-RNA interactome datasets. While the characterization of multiple sRNAs has helped to elucidate their mechanisms of action, these studies also are providing insights into protein function, control of metabolic flux, and connections between metabolic pathways as we will discuss here. In describing several examples of the metabolic insights gained, we will summarize the different types of base-pairing sRNAs including mRNA-derived sRNAs, sponge RNAs, RNA mimics, and dual-function RNAs as well as suggest how information about sRNAs could be exploited in the future.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bacteria
/
RNA, Bacterial
/
RNA, Small Untranslated
Language:
En
Journal:
Cell Chem Biol
Year:
2024
Document type:
Article
Country of publication:
Estados Unidos