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Antimicrobial susceptibility analysis of isepamicin combination treatments in Mycobacterium abscessus species.
Kato, Yukari; Ihara, Hiroaki; Takei, Satomi; Nakamura, Ayako; Fujimoto, Yuichi; Handoh, Tetsuya; Kurokawa, Kana; Arai, Yuta; Shibayama, Kohei; Sumiyoshi, Issei; Ochi, Yusuke; Watanabe, Junko; Hoshi, Kazuaki; Misawa, Shigeki; Togo, Shinsaku; Naito, Toshio; Tabe, Yoko; Miida, Takashi; Takahashi, Kazuhisa.
Affiliation
  • Kato Y; Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Ihara H; Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Takei S; Koto Hospital, Tokyo, Japan.
  • Nakamura A; Department of Clinical Laboratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Fujimoto Y; Juntendo Tokyo Koto Geriatric Medical Center, Tokyo, Japan.
  • Handoh T; Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Kurokawa K; Department of Clinical Laboratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Arai Y; Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Shibayama K; Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Sumiyoshi I; Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Ochi Y; Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Watanabe J; Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Hoshi K; Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Misawa S; Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Togo S; Leading Center for the Development and Research of Cancer Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Naito T; Department of Clinical Laboratory Technology, Juntendo University, Faculty of Medical Science, Tokyo, Japan.
  • Tabe Y; Department of Respiratory Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Miida T; Research Institute for Diseases of Old Ages, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
  • Takahashi K; Department of General Medicine, Graduate School of Medicine, Juntendo University, Faculty of Medicine, Tokyo, Japan.
J Clin Tuberc Other Mycobact Dis ; 36: 100464, 2024 Aug.
Article in En | MEDLINE | ID: mdl-39099802
ABSTRACT
This study evaluated the antimicrobial potency of the combination of isepamicin (ISP) for Mycobacterium abscessus species (MABS). 34 clinical MABS strains were isolated from clinical samples. Of them, 11 (32.4 %) were M. abscessus subsp. abscessus (Mab), 22 (64.7 %) were M. abscessus subsp. massiliense (Mma), and one (2.9 %) was M. abscessus subsp. bolletii (Mbo). We compared susceptibility to sitafloxacin (STFX)-ISP and clarithromycin (CLR)-ISP combinations with those of the antimicrobial agents alone, and synergistic effects were observed in 41.2 % and 17.6 % when treated with STFX-ISP and CLR-ISP. By hierarchical cluster analysis, the isolates divided into treatment-sensitive and treatment-resistant groups. Non-Mma or rough colony isolates were significantly likely to belong to the treatment-sensitive group (p = 0.024, p < 0.001, respectively). These results suggest that the ISP-containing combination could be a new therapeutic strategy for MABS, especially in cases of non-Mma treatment-refractory subspecies, and rough morphotypes high-virulence morphotypes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Clin Tuberc Other Mycobact Dis Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: J Clin Tuberc Other Mycobact Dis Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Reino Unido