Pluripotent stem cell-derived organoids: A brief history of curiosity-led discoveries.
Bioessays
; : e2400105, 2024 Aug 05.
Article
in En
| MEDLINE
| ID: mdl-39101295
ABSTRACT
Organoids are quickly becoming an accepted model for understanding human biology and disease. Pluripotent stem cells (PSC) provide a starting point for many organs and enable modeling of the embryonic development and maturation of such organs. The foundation of PSC-derived organoids can be found in elegant developmental studies demonstrating the remarkable ability of immature cells to undergo histogenesis even when taken out of the embryo context. PSC-organoids are an evolution of earlier methods such as embryoid bodies, taken to a new level with finer control and in some cases going beyond tissue histogenesis to organ-like morphogenesis. But many of the discoveries that led to organoids were not necessarily planned, but rather the result of inquisitive minds with freedom to explore. Protecting such curiosity-led research through flexible funding will be important going forward if we are to see further ground-breaking discoveries.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Bioessays
Journal subject:
BIOLOGIA
/
BIOLOGIA MOLECULAR
Year:
2024
Document type:
Article
Affiliation country:
Reino Unido
Country of publication:
Estados Unidos