Physiologically based pharmacokinetic modeling in obesity: applications and challenges.
Expert Opin Drug Metab Toxicol
; 20(8): 805-816, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-39101366
ABSTRACT
INTRODUCTION:
Rising global obesity rates pose a threat to people's health. Obesity causes a series of pathophysiologic changes, making the response of patients with obesity to drugs different from that of nonobese, thus affecting the treatment efficacy and even leading to adverse events. Therefore, understanding obesity's effects on pharmacokinetics is essential for the rational use of drugs in patients with obesity. AREAS COVERED Articles related to physiologically based pharmacokinetic (PBPK) modeling in patients with obesity from inception to October 2023 were searched in PubMed, Embase, Web of Science and the Cochrane Library. This review outlines PBPK modeling applications in exploring factors influencing obesity's effects on pharmacokinetics, guiding clinical drug development and evaluating and optimizing clinical use of drugs in patients with obesity. EXPERT OPINION Obesity-induced pathophysiologic alterations impact drug pharmacokinetics and drug-drug interactions (DDIs), altering drug exposure. However, there is a lack of universal body size indices or quantitative pharmacology models to predict the optimal for the patients with obesity. Therefore, dosage regimens for patients with obesity must consider individual physiological and biochemical information, and clinically individualize therapeutic drug monitoring for highly variable drugs to ensure effective drug dosing and avoid adverse effects.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pharmacokinetics
/
Drug Interactions
/
Drug Development
/
Models, Biological
/
Obesity
Limits:
Animals
/
Humans
Language:
En
Journal:
Expert Opin Drug Metab Toxicol
/
Expert opinion on drug metabolism & toxicology (Online)
Journal subject:
METABOLISMO
/
TOXICOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Reino Unido