Contributions of T Cell Signaling for Wound Healing.
J Burn Care Res
; 2024 Aug 07.
Article
in En
| MEDLINE
| ID: mdl-39110034
ABSTRACT
It has long been known that T cells participate in wound healing, however, it is still enigmatic about the landscape of the signaling derived from T cells in the process of wound healing. With the advantages of scRNA-seq, in combination of immunofluorescent imaging, we identified activated T cells, cytotoxic T cells (CTLs), exhausting T cells and Tregs existing in inflammation phase of wound healing. Further analysis revealed each T cell population possess distinguished signals contributed to wound healing, some are critical for improving the wound healing quality. Besides, this study discovered and validated the exhistance of exhausting T cells among the T cells accumulated in skin duing wound healing, and the molecular mechanism(s) and contribution of exhausting T cells to wound healing deserves extensive studies in the future.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Burn Care Res
Journal subject:
TRAUMATOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
China