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Mechanisms of age-related Treg dysfunction in an arthritic environment.
Nishiyama, Taihei; Ohyama, Ayako; Miki, Haruka; Asashima, Hiromitsu; Kondo, Yuya; Tsuboi, Hiroto; Ohno, Hiroshi; Shimano, Hitoshi; Matsumoto, Isao.
Affiliation
  • Nishiyama T; Department of Rheumatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Ohyama A; Department of Rheumatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Miki H; Department of Rheumatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Asashima H; Department of Rheumatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Kondo Y; Department of Rheumatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Tsuboi H; Department of Rheumatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Ohno H; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Shimano H; Department of Endocrinology and Metabolism, Institute of Medicine, University of Tsukuba, Tsukuba, Japan.
  • Matsumoto I; Department of Rheumatology, Institute of Medicine, University of Tsukuba, Tsukuba, Japan. Electronic address: ismatsu@md.tsukuba.ac.jp.
Clin Immunol ; 266: 110337, 2024 Sep.
Article in En | MEDLINE | ID: mdl-39111562
ABSTRACT
Rheumatoid arthritis (RA) is an autoimmune disease characterized by a polyarticular synovitis. In recent years, elderly onset rheumatoid arthritis (EORA) has been increasing. Treg cells in RA have been reported to be dysfunctional, but the relationship between aging and their functional changes is unclear. Here, we found that Treg cells from EORA patients had increased percentages, but decreased activity compared to those from younger onset RA (YORA) patients. In experiments using arthritis model mice, decreased suppressive function and oxygen consumption rate (OCR) were observed in Treg cells only from old arthritic mice. Furthermore, type I interferon (IFN) signaling was upregulated in Treg cells from old GIA mice, and IFN-ß decreased the suppressive function of Treg cells. Our findings demonstrate that increased type I IFN signaling in old Treg cells is induced only in the arthritic environment and relates to decreased suppressive function of Treg cells, gets involved in EORA.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Aging / T-Lymphocytes, Regulatory Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Aging / T-Lymphocytes, Regulatory Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: Clin Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos