Efficacy of transarterial chemoembolization treatment with 30-60-µm microspheres in patients with hepatocellular carcinoma.
Radiologie (Heidelb)
; 2024 Aug 07.
Article
in En
| MEDLINE
| ID: mdl-39112640
ABSTRACT
BACKGROUND:
Chemoembolization with small drug-eluting microspheres is widely used in the treatment of hepatocellular carcinoma (HCC).OBJECTIVES:
This study aimed to evaluate the efficacy and safety of transarterial chemoembolization with doxorubicin-eluting 30-60-µm microspheres (DEB-TACE) in patients with Barcelona Clinic Liver Cancer (BCLC) stage A and B HCC. MATERIALS ANDMETHODS:
In this single-center study, 88 patients with HCC (BCLC A/B 15.9%/84.1%) who underwent 137 DEB-TACE sessions between January 2015 and December 2020 were retrospectively assessed. Response to treatment was assessed 4-8 weeks after each DEB-TACE procedure according to mRECIST (Modified Response Evaluation Criteria in Solid Tumors) criteria. Progression-free survival (PFS), time to progression (TTP), overall survival (OS), and adverse events were recorded.RESULTS:
In 88 patients (84.1% males; median age, 66.0 years; range, 22-83), the median follow-up was 17 months (range, 2-64). Eight patients (9.1%) had a complete response, 42 (47.8%) had partial regression, 10 (11.3%) had stable disease, and 28 (31.8%) had progressive disease. There was a statistically significant difference between serum alpha-fetoprotein (AFP) levels before and after DEB-TACE treatment (pâ¯< 0.001). The median OS was 17 months (95% confidence interval [CI], 10.3-23.7). Cox regression analyses found that preprocedural serum AFP level (400+ vs. <â¯400; pâ¯= 0.024), Child Pugh classification (B vs. A; pâ¯= 0.019), and number of DEB-TACE sessions (1 vs. >â¯1; pâ¯= 0.003) were independent risk factors affecting OS. The median PFS was 8 months (95% CI, 5.8-10.2) and TTP was 6 months (1-14 months).CONCLUSION:
Chemoembolization with 30-60-µm microspheres is an effective and safe treatment for HCC. The number of DEB-TACE sessions is also one of the factors affecting OS.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Radiologie (Heidelb)
Year:
2024
Document type:
Article
Affiliation country:
Turquía