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Prescriptions of anti-reflux drugs in neonatology and neonatal intensive care units: A large multicentre observational study (2014-2022).
Tauzin, Manon; Gouyon, Béatrice; Liu, Jiao; Lapillonne, Alexandre; Lorrain, Simon; Bellaiche, Marc; Jung, Camille.
Affiliation
  • Tauzin M; Neonatal Intensive Care Unit, Centre Hospitalier Intercommunal de Créteil (CHIC), Créteil, France.
  • Gouyon B; Centre d'Études Périnatales de l'Océan Indien (CEPOI, EA7388), Université de La Réunion, Saint-Pierre, France.
  • Liu J; Clinical Research Center, CHIC, Créteil, France.
  • Lapillonne A; Neonatal Intensive Care Unit, APHP Necker-Enfants Malades Hospital, Paris Université, Paris, France.
  • Lorrain S; Centre d'Études Périnatales de l'Océan Indien (CEPOI, EA7388), Université de La Réunion, Saint-Pierre, France.
  • Bellaiche M; Department of Pediatric Gastroenterology, Robert Debré Hospital, Paris, France.
  • Jung C; Clinical Research Center, CHIC, Créteil, France.
Br J Clin Pharmacol ; 2024 Aug 07.
Article in En | MEDLINE | ID: mdl-39113184
ABSTRACT

AIMS:

Gastro-oesophageal reflux is common in newborns, especially in premature infants. Treatment by medication is controversial as the drugs prescribed have not been consistently proven to be effective and are known to have adverse effects. This study sought to identify trends in the prescription of anti-reflux medication in a large group of French neonatal units.

METHODS:

Data on prescriptions of anti-reflux treatments-proton pump inhibitors (PPIs), antacids, histamine-2 receptor antagonists (H2RAs), and prokinetics-from 2014 to 2022 for infants with a corrected gestational age <45 weeks, were extracted from a prescription database (Logipren®) used by 63 French neonatal units, and then analysed.

RESULTS:

Of all infants recorded in the database during the study period (n = 152 743), 10.2% (n = 15 650) were prescribed anti-reflux medication (95% confidence interval [CI] 10.0-10.4%), mainly as monotherapy (77.5%). The rate was higher in the subgroup of preterm infants born before 28 weeks of gestation (n = 9493) (20.6%, 95% CI 19.8-21.4%; n = 1956). PPIs were the most commonly prescribed anti-reflux medications (6.9% of infants, 95% CI 6.8-7.0), followed by antacids (5.2%, 95% CI 5.1-5.3%), while H2RAs and prokinetics were rarely prescribed. Over the period, the prescription rate remained stable for PPIs, decreased for H2RAs (τ = -0.86, P = .02), and, among preterm infants born at gestational ages of 28-31 or 32-36 weeks, increased for antacids.

CONCLUSIONS:

Anti-reflux medications were frequently prescribed by neonatal units, especially for extremely premature infants. Most of these prescriptions were for PPIs and antacids.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Br J Clin Pharmacol Year: 2024 Document type: Article Affiliation country: Francia Country of publication: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Br J Clin Pharmacol Year: 2024 Document type: Article Affiliation country: Francia Country of publication: Reino Unido