The Crosstalk Between Amyloid-ß, Retina, and Sleep for the Early Diagnosis of Alzheimer's Disease: A Narrative Review.
J Alzheimers Dis Rep
; 8(1): 1009-1021, 2024.
Article
in En
| MEDLINE
| ID: mdl-39114553
ABSTRACT
Alzheimer's disease (AD) is the most common type of dementia, which is characterised by progressive memory loss and accumulation of hallmark markers amyloid-ß (Aß) and neurofibrillary tangles in the diseased brain. The current gold standard diagnostic methods have limitations of being invasive, costly, and not easily accessible. Thus, there is a need for new avenues, such as imaging the retina for early AD diagnosis. Sleep disruption is symptomatically frequent across preclinical and AD subjects. As circadian activity, such as the sleep-wake cycle, is linked to the retina, analysis of their association may be useful additions for achieving predictive AD diagnosis. In this narrative review, we provide an overview of human retina studies concerning the deposition of Aß, the role of the retina in sleep-wake cycle, the disruption of sleep in AD, and to gather evidence for the associations between Aß, the retina, and sleep. Understanding the mechanisms behind the associations between Aß, retina, and sleep could assist in the interpretation of retinal changes accurately in AD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Alzheimers Dis Rep
Year:
2024
Document type:
Article
Affiliation country:
Australia
Country of publication:
Países Bajos