Costs of care during chimeric antigen receptor T-cell therapy in relapsed or refractory B-cell lymphomas.
JNCI Cancer Spectr
; 8(4)2024 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-39115391
ABSTRACT
High upfront cost may be a barrier to adopting chimeric antigen receptor T-cell (CAR-T) therapy for relapsed or refractory B-cell lymphoma. Data on the real-world costs are limited. Using the Blue Cross Blue Shield Axis database, we evaluated 271 commercially insured patients who received CAR-T therapy for B-cell lymphoma (median age = 58 years; men = 68%; diffuse large B-cell lymphoma = 87%; inpatient CAR-T therapy = 85%). Our peri-CAR-T period of interest was from 41 days before to 154 days after CAR-T therapy index divided into seven 28-day intervals. Median total costs were $608â100 (interquartile range, IQR = $534â100-$732â800); 8.5% of patients had total costs exceeding $1 million. The median cost of CAR-T therapy products was $402â500, and the median out-of-pocket copayment was $510. Monthly costs were highest during the month of CAR-T therapy administration (median = $521â500), with median costs below $25â000 in all other 28-day intervals. Costs of CAR-T therapy use were substantial, largely driven by product acquisition. Future studies should examine the relationship between costs, access, and financial outcomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunotherapy, Adoptive
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Lymphoma, Large B-Cell, Diffuse
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Receptors, Chimeric Antigen
Limits:
Aged
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Female
/
Humans
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Male
/
Middle aged
Language:
En
Journal:
JNCI Cancer Spectr
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos
Country of publication:
Reino Unido