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Photoredox-catalyzed C(sp2)-H trifluoromethylation of 3-methylene-isoindolin-1-ones under metal-free conditions.
Zhou, Yuan-Xia; Liu, Feng-Qian; Wang, Guo-Qin; Yang, Dan; Han, Pan; Jing, Lin-Hai.
Affiliation
  • Zhou YX; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China. danyangchem@mail.nankai.edu.cn.
  • Liu FQ; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China. danyangchem@mail.nankai.edu.cn.
  • Wang GQ; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China. danyangchem@mail.nankai.edu.cn.
  • Yang D; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China. danyangchem@mail.nankai.edu.cn.
  • Han P; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China. danyangchem@mail.nankai.edu.cn.
  • Jing LH; Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637002, China. danyangchem@mail.nankai.edu.cn.
Org Biomol Chem ; 22(34): 6928-6932, 2024 Aug 28.
Article in En | MEDLINE | ID: mdl-39119751
ABSTRACT
A facile synthetic method for direct C(sp2)-H bond trifluoromethylation of 3-methylene-isoindolin-1-ones under visible-light-induced metal-free conditions is presented. This protocol features mild reaction conditions, broad substrate scope and excellent functional group tolerance, resulting in a range of structurally diverse trifluoromethylated products in good to excellent yields.

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Document type: Article Affiliation country: China Country of publication: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Org Biomol Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2024 Document type: Article Affiliation country: China Country of publication: Reino Unido