Interobserver and intraobserver agreement in PET/CT with [18F]DCFPyL according to TNM molecular and PSMA-RADS 2.0 criteria.
Rev Esp Med Nucl Imagen Mol (Engl Ed)
; : 500047, 2024 Aug 08.
Article
in En
| MEDLINE
| ID: mdl-39121988
ABSTRACT
PURPOSE:
The aim of this study was to determine the agreement between three observers with different levels of experience using the PSMA-RADS 2.0 criteria and the miTNM system for the interpretation of PET-PSMA with [18F]DCFPyL in males with prostate cancer. MATERIALS ANDMETHODS:
PET-PSMA images from 114 prostate cancer patients were blindly reported twice by three different observers at intervals of 8 weeks. The evaluations were performed according to the molecular imaging TNM (miTNM) and PSMA-RADS 2.0 criteria. We used Fleiss' Kappa to analyse inter and intraobserver agreements.RESULTS:
Moderate overall agreement was obtained in the assessment of the PET-PSMA results (Fleiss'kâ¯=â¯0.53; 95% CI 0.45-0.62; pâ¯<â¯0.001), with significant agreement in the miT, miN and miM reports. There was a substantial level of agreement in the reporting of prostatic disease and lymphatic involvement (Fleiss'kâ¯=â¯0.66 and 0.65), being lower than that observed in the reporting of metastatic disease (Fleiss'kâ¯=â¯0.86), especially in the M0 group (Fleiss'kâ¯=â¯0.99). Upon re-evaluation of the images, observer 1 had moderate overall agreement for miT (Fleiss'kâ¯=â¯0.51) and substantial agreement for miN and miM (Fleiss'k 0.75 and 0.63, respectively).CONCLUSIONS:
The use of a structured scoring system such as PSMA-RADS 2.0, as well as the miTNM classification system in the interpretation of PET-PSMA images in prostate cancer patients, provides a highly reproducible report format. High levels of interobserver and intraobserver agreement are found, especially when ruling out disease, which supports its use in routine clinical practice.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Rev Esp Med Nucl Imagen Mol (Engl Ed)
Year:
2024
Document type:
Article