Advancements in the Research of New Modulators of Nitric Oxide Synthases Activity.
Int J Mol Sci
; 25(15)2024 Aug 03.
Article
in En
| MEDLINE
| ID: mdl-39126054
ABSTRACT
Nitric oxide (NO) has been defined as the "miracle molecule" due to its essential pleiotropic role in living systems. Besides its implications in physiologic functions, it is also involved in the development of several disease states, and understanding this ambivalence is crucial for medicinal chemists to develop therapeutic strategies that regulate NO production without compromising its beneficial functions in cell physiology. Although nitric oxide synthase (NOS), i.e., the enzyme deputed to the NO biosynthesis, is a well-recognized druggable target to regulate NO bioavailability, some issues have emerged during the past decades, limiting the progress of NOS modulators in clinical trials. In the present review, we discuss the most promising advancements in the research of small molecules that are able to regulate NOS activity with improved pharmacodynamic and pharmacokinetic profiles, providing an updated framework of this research field that could be useful for the design and development of new NOS modulators.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nitric Oxide Synthase
/
Enzyme Inhibitors
/
Nitric Oxide
Limits:
Animals
/
Humans
Language:
En
Journal:
Int J Mol Sci
Year:
2024
Document type:
Article
Affiliation country:
Italia
Country of publication:
Suiza