Diabetes mellitus and the risk of spontaneous bacterial peritonitis in patients with liver cirrhosis: a systematic review and meta-analysis.
Ann Saudi Med
; 44(4): 272-287, 2024.
Article
in En
| MEDLINE
| ID: mdl-39127903
ABSTRACT
BACKGROUND:
Spontaneous bacterial peritonitis (SBP) represents a critical and potentially lethal condition that typically develops in individuals with liver cirrhosis. This meta-analysis aimed to assess diabetes mellitus (DM) as a risk factor for SBP in liver cirrhotic patients.METHODS:
Following PRISMA guidelines, fifteen studies were included, for a total of 76 815 patients. The risk of bias was assessed using the Newcastle-Ottawa scale (NOS). We represented the results as risk ratios (RR) with the corresponding 95% confidence intervals (CI) using RevMan software. Additionally, we pooled the hazard ratios (HR) for developing SBP in patients with DM from the included studies.RESULTS:
The meta-analysis shows a significantly increased risk of SBP in cirrhotic patients with DM (HR 1.26; 95% CI [1.05-1.51], P=.01; HR 1.70; 95% CI [1.32-2.18], P<.001).CONCLUSIONS:
The study signifies that DM is an independent risk factor for SBP, emphasizing the need for targeted preventive measures in this specific population.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peritonitis
/
Bacterial Infections
/
Liver Cirrhosis
Limits:
Humans
Language:
En
Journal:
Ann Saudi Med
Journal subject:
MEDICINA
Year:
2024
Document type:
Article
Affiliation country:
Arabia Saudita
Country of publication:
Arabia Saudita