Revealing the impact of modified modules flexibility on gemcitabine prodrug nanoassemblies for effective cancer therapy.
J Colloid Interface Sci
; 677(Pt A): 941-952, 2025 Jan.
Article
in En
| MEDLINE
| ID: mdl-39128288
ABSTRACT
Prodrug nanoassemblies combine the advantages of prodrug strategies and nanotechnology have been widely utilized for delivering antitumor drugs. These prodrugs typically comprise active drug modules, response modules, and modification modules. Among them, the modification modules play a critical factor in improving the self-assembly ability of the parent drug. However, the impact of the specific structure of the modification modules on prodrug self-assembly remains elusive. In this study, two gemcitabine (GEM) prodrugs are developed using 2-octyl-1-dodecanol (OD) as flexible modification modules and cholesterol (CLS) as rigid modification modules. Interestingly, the differences in the chemical structure of modification modules significantly affect the assembly performance, drug release, cytotoxicity, tumor accumulation, and antitumor efficacy of prodrug nanoassemblies. It is noteworthy that the prodrug nanoassemblies constructed with flexible modifying chains (OD) exhibit improved stability, faster drug release, and enhanced antitumor effects. Our findings elucidate the significant impact of modification modules on the construction of prodrug nanoassemblies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prodrugs
/
Deoxycytidine
/
Drug Liberation
/
Gemcitabine
Limits:
Animals
/
Humans
Language:
En
Journal:
J Colloid Interface Sci
/
J. colloid interface sci
/
Journal of colloid and interface science
Year:
2025
Document type:
Article
Affiliation country:
China
Country of publication:
Estados Unidos