A Structural Mimic of Carbonic Anhydrase in Zeolitic Imidazolate Frameworks via Trans-functionalization for Enhancing Hydrolytic Activity.
Research (Wash D C)
; 7: 0434, 2024.
Article
in En
| MEDLINE
| ID: mdl-39130495
ABSTRACT
Metal-organic frameworks (MOFs) have been widely considered as ideal platforms for the preparation of biomimetic catalysts, but it remains challenging to fabricate MOF-based enzyme-like catalysts with optimal activity. Here, we leverage the inherent flexibility of MOFs and propose a novel trans-functionalization strategy to construct a carbonic anhydrase (CA) mimic by the structural transformation from ZIF-L to ZIF-8. Theoretical and experimental results reveal that during the structural transformation, the hydroxyl group will preferentially coordinate with the interlayer Zn clusters to form the CA-like active center Zn-N3-OH. Therefore, more accessible active centers are generated on the as-prepared ZIF-8-OH, resulting in substantially enhanced catalytic activity in the hydrolysis of para-nitrophenyl acetate.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Research (Wash D C)
Year:
2024
Document type:
Article
Country of publication:
Estados Unidos