Immunomodulatory Antibacterial Hydrogel for Wound Infection Management.
Int J Nanomedicine
; 19: 8159-8174, 2024.
Article
in En
| MEDLINE
| ID: mdl-39139505
ABSTRACT
Background:
Wound healing has always been a focal point in clinical work. Bacterial infections and immune microenvironment disorders can both hinder normal wound healing. Current wound dressings only serve a covering function. Developing wound dressings with antibacterial and immunomodulatory functions is crucial for aiding wound healing. To address this issue, we have developed a hydrogel with antibacterial and immunomodulatory functions for managing infected wounds.Methods:
The present study describes a photo-crosslinked antibacterial hydrogel composed of curcumin, silver nanoparticles-loaded reduced graphene oxide, and silk fibroin methacryloyl for the treatment of infected wounds. The study assessed its antibacterial properties and its capacity to induce macrophage M2 polarization through in vitro and in vivo experiments.Results:
The hydrogel demonstrates robust antibacterial properties and enhances macrophage M2 polarization in both in vitro and in vivo settings. Moreover, it accelerates the healing of infected wounds in vivo by stimulating collagen deposition and angiogenesis.Conclusion:
Overall, this hydrogel shows great potential in managing wound infections.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Silver
/
Wound Healing
/
Wound Infection
/
Hydrogels
/
Metal Nanoparticles
/
Graphite
/
Anti-Bacterial Agents
Limits:
Animals
/
Humans
/
Male
Language:
En
Journal:
Int J Nanomedicine
Year:
2024
Document type:
Article
Country of publication:
Nueva Zelanda