Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases.
Clin Immunol
; 267: 110338, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39142493
ABSTRACT
The pathogenesis and manifestation of autoimmune thyroid diseases (AITDs), Graves' disease (GD), and Hashimoto's disease (HD) are associated with T cell activation. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a crucial role in the regulation of T cell activation. DNA methylation levels of eight CpG sites in the CTLA4 gene and expression levels of soluble CTLA-4 were examined. Methylation levels of +22 CpG and CT60 CpG-SNPs in patients with GD and HD with the CT60 GG genotype were lower than those in control subjects. Methylation levels of the-15 CpG sites were lower in patients with intractable GD than those in GD patients in remission. These results suggest that demethylation of +22 CpG and CT60 CpG-SNPs may be associated with susceptibility to GD and HD in subjects with the CTLA4 CT60 GG genotype, and that demethylation of -15 CpG may be associated with the intractability of GD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Graves Disease
/
DNA Methylation
/
Hashimoto Disease
/
CTLA-4 Antigen
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Clin Immunol
Journal subject:
ALERGIA E IMUNOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Japón
Country of publication:
Estados Unidos