Protective Effect of Carvacrol against Oxidative Damage in Aged Rats.
Cent Nerv Syst Agents Med Chem
; 2024 Aug 13.
Article
in En
| MEDLINE
| ID: mdl-39143874
ABSTRACT
BACKGROUND:
Aging affects cellular functions and impairs tissue homeostasis. Carvacrol, a polyphenolic compound, has been shown to exert a wide range of pharmacological effects, such as antioxidant, anti-inflammatory, and anticancer characteristics.METHODS:
This investigation aimed to evaluate the effect of carvacrol in elderly male rats. Carvacrol at a dose of 15 or 30 mg/kg was administrated daily per os for 60 days to aged rats. The liver, heart, and kidney samples were taken for the analysis of oxidative stress markers. Serum samples were used to evaluate liver enzymes (alanine transaminase (ALT) and aspartate aminotransferase (AST)).RESULTS:
The levels of malondialdehyde (MDA) in the liver, heart, and kidney tissues of aged rats were higher. Conversely, the level of thiol was lower in the mentioned tissues than in the young control group. The levels of MDA in the liver, heart, and kidney tissues of aged rats were significantly reduced by carvacrol, which was accompanied by increased levels of total thiol. ALT and AST levels were higher in the serum of aged rats than in the young control ones. Carvacrol decreased ALT and AST levels in the serum of aged rats versus aged control rats.CONCLUSION:
Carvacrol can be effective in protecting susceptible aged tissues and organs by increasing antioxidant defenses and decreasing liver enzymes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Cent Nerv Syst Agents Med Chem
/
Cent. nerv. syst. agents med. chem
/
Central nervous systen agents in medicinal chemistry
Journal subject:
FARMACOLOGIA
/
NEUROLOGIA
/
QUIMICA CLINICA
Year:
2024
Document type:
Article
Affiliation country:
Irán
Country of publication:
Emiratos Árabes Unidos