The clinical effect of Dienogest on urinary and sexual symptoms in endometriosis patients.

ABSTRACT

BACKGROUND: To evaluate the effect on urinary symptoms and sexual functioning of Dienogest within a 6-month period of follow-up. METHODS: A total of 22 women who were diagnosed as having endometriosis with pelvic pain and irritative urinary symptoms were recruited in this study. The participating patients took a daily dose of 2 mg DNG and underwent outpatient visits at the beginning, 1, 2, 3 and 6 months following treatment. RESULTS: Our data showed a significant improvement of the VAS score since the 1st month till the 6th month after treatment of DNG. OABSS, UDI-6 and IIQ-7 were significantly improved after the treatment of DNG. Besides, serum estradiol was also decreased. Our data also showed that DNG treatment for 6 months did not affect FSFI score. Some patients with heavy menstruation were also improved; however, some patients with regular periods missed or dropped a period after DNG treatment, while other adverse effects were also shown. CONCLUSION: Our study demonstrated that DNG could not only alleviate endometriosis pelvic pain but reduce urinary symptoms within the 6-month follow-up as well. DNG did not affect sexual function in FSFI score, although some adverse effects were recorded.