Mapping autophagy-related membrane contact site proteins and complexes with AutoMCS Navigator.
Autophagy
; : 1-3, 2024 Aug 27.
Article
in En
| MEDLINE
| ID: mdl-39171722
ABSTRACT
In eukaryotic cells, membrane contact sites (MCSs) mediate interactions and communication between organelles by bringing their membranes into close proximity without fusion. These sites play crucial roles in intracellular transport, signal transduction, and the regulation of organelle functions. In a recent study, we compiled data on MCS proteins and complexes from publications to create the MCSdb database. During data compilation, we discovered that many MCSs, their associated proteins, and complexes are highly relevant to macroautophagy/autophagy. To elucidate the role of MCSs in autophagy, we reorganized the autophagy-related MCS proteins and complexes from MCSdb, creating a data map called AutoMCS Navigator. The current version of this map includes 30 complexes and 84 proteins, covering 13 different MCSs and 7 species. Meanwhile, we embedded a dedicated webpage for AutoMCS Navigator on the MCSdb website. This webpage features an orchestrated visual guide that hierarchically displays MCS proteins and complexes involved in autophagy. In summary, our research has developed a user-friendly visual map for querying, browsing, and visualizing detailed information on autophagy-related MCS proteins and complexes. This tool offers researchers easy access to understand autophagy-related MCS structure, assembly, functions, and therapeutic strategies for related diseases. AutoMCS Navigator is freely available at https//cellknowledge.com.cn/mcsdb/autophagy.html.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Autophagy
Year:
2024
Document type:
Article
Affiliation country:
Japón
Country of publication:
Estados Unidos