Your browser doesn't support javascript.
loading
Sex-Dependent Effects of Cardiometabolic Health and APOE4 on Brain Age: A Longitudinal Cohort Study.
Subramaniapillai, Sivaniya; Schindler, Louise S; Redmond, Paul; Bastin, Mark E; Wardlaw, Joanna M; Valdés Hernández, Maria; Maniega, Susana Muñoz; Aribisala, Benjamin; Westlye, Lars T; Coath, William; Groves, James; Cash, David M; Barnes, Josephine; James, Sarah-Naomi; Sudre, Carole H; Barkhof, Frederik; Richards, Marcus; Corley, Janie; Russ, Tom C; Cox, Simon R; Schott, Jonathan M; Cole, James H; de Lange, Ann-Marie G.
Affiliation
  • Subramaniapillai S; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Schindler LS; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Redmond P; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Bastin ME; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Wardlaw JM; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Valdés Hernández M; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Maniega SM; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Aribisala B; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Westlye LT; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Coath W; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Groves J; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Cash DM; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Barnes J; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • James SN; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Sudre CH; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Barkhof F; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Richards M; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Corley J; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Russ TC; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Cox SR; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Schott JM; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • Cole JH; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
  • de Lange AG; From the Department of Clinical Neuroscience (S.S., L.S.S., A.-M.G.d.L.), Lausanne University Hospital and University of Lausanne, Switzerland; Department of Psychology (P.R., M.E.B., J.M.W., M.V.H., S.M.M., B.A., J.C., T.C.R., S.R.C.), University of Edinburgh, United Kingdom; Department of Psycholo
Neurology ; 103(6): e209744, 2024 Sep 24.
Article in En | MEDLINE | ID: mdl-39173100
ABSTRACT
BACKGROUND AND

OBJECTIVES:

The aging population is growing faster than all other demographic strata. With older age comes a greater risk of health conditions such as obesity and high blood pressure (BP). These cardiometabolic risk factors (CMRs) exhibit prominent sex differences in midlife and aging, yet their influence on brain health in females vs males is largely unexplored. In this study, we investigated sex differences in relationships between BP, body mass index (BMI), and brain age over time and tested for interactions with APOE ε4 genotype (APOE4), a known genetic risk factor of Alzheimer disease.

METHODS:

The sample included participants from 2 United Kingdom-based longitudinal birth cohorts, the Lothian Birth Cohort (1936) and Insight 46 (1946). Participants with MRI data from at least 1 time point were included to evaluate sex differences in associations between CMRs and brain age. The open-access software package brainageR 2.1 was used to estimate brain age for each participant. Linear mixed-effects models were used to assess the relationships between brain age, BMI, BP, and APOE4 status (i.e., carrier vs noncarrier) in males and females over time.

RESULTS:

The combined sample comprised 1,120 participants (48% female) with a mean age (SD) of 73 (0.72) years in the Lothian Birth Cohort and 71 (0.68) years in Insight 46 at the time point 1 assessment. Approximately 30% of participants were APOE4 carriers. Higher systolic and diastolic BP was significantly associated with older brain age in females only (ß = 0.43-0.56, p < 0.05). Among males, higher BMI was associated with older brain age across time points and APOE4 groups (ß = 0.72-0.77, p < 0.05). In females, higher BMI was linked to older brain age among APOE4 noncarriers (ß = 0.68-0.99, p < 0.05), whereas higher BMI was linked to younger brain age among carriers, particularly at the last time point (ß = -1.75, p < 0.05).

DISCUSSION:

This study indicates sex-dependent and time-dependent relationships between CMRs, APOE4 status, and brain age. Our findings highlight the necessity of sex-stratified analyses to elucidate the role of CMRs in individual aging trajectories, providing a basis for developing personalized preventive interventions.
Subject(s)
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Aging / Body Mass Index / Sex Characteristics / Apolipoprotein E4 Limits: Aged / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Neurology Year: 2024 Document type: Article Country of publication: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Aging / Body Mass Index / Sex Characteristics / Apolipoprotein E4 Limits: Aged / Female / Humans / Male Country/Region as subject: Europa Language: En Journal: Neurology Year: 2024 Document type: Article Country of publication: Estados Unidos