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Conditionally restricted detection of nitrite under acidic conditions by activatable fluorescent probes.
Wang, Xiang; Guo, Yu; Zhao, Long; Yang, Yuqin; Wei, Peng; Yi, Tao.
Affiliation
  • Wang X; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
  • Guo Y; Department of Laboratory Animal Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China.
  • Zhao L; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
  • Yang Y; Department of Laboratory Animal Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Electronic address: fudanyan2007@sina.com.
  • Wei P; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China. Electronic address: weipeng@
  • Yi T; State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China. Electronic address: yitao@dh
J Hazard Mater ; 478: 135495, 2024 Oct 05.
Article in En | MEDLINE | ID: mdl-39181006
ABSTRACT
As a commonly used food additive, excessive nitrite intake seriously affects people's health in daily life. As the stomach is the main organ involved in nitrite intake, achieving fast and in situ detection of nitrite in the stomach is of great significance for avoiding the hazards caused by nitrite. However, owing to the poor stability or low sensitivity of existing fluorescent probes under acidic conditions, their application for nitrite detection within the stomach remains challenging. To solve this problem, we developed novel probes specifically designed to maintain stability and demonstrate high sensitivity to nitrite under acidic conditions. Utilizing the optimized probe (DHUROS-11), nitrite levels in environmental and real samples were successfully quantified. Notably, tracing of nitrite within the stomach of mice in real time was realized by using DHUROS-11 as the probe.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fluorescent Dyes / Nitrites Limits: Animals Language: En Journal: J Hazard Mater / J. hazard. mater / Journal of hazardous materials Journal subject: SAUDE AMBIENTAL Year: 2024 Document type: Article Affiliation country: China Country of publication: Países Bajos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fluorescent Dyes / Nitrites Limits: Animals Language: En Journal: J Hazard Mater / J. hazard. mater / Journal of hazardous materials Journal subject: SAUDE AMBIENTAL Year: 2024 Document type: Article Affiliation country: China Country of publication: Países Bajos