Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
Biochem Biophys Res Commun
; 739: 150587, 2024 Aug 22.
Article
in En
| MEDLINE
| ID: mdl-39182353
ABSTRACT
Intervertebral disc degeneration (IDD) is a common cause of low back pain and disability. Recent studies have highlighted the critical role of mitochondrial dysfunction in the progression of IDD. In this study, we investigated the therapeutic potential of taurine in delaying IDD through the activation of mitophagy via the PINK1/Parkin pathway. Our in vitro and in vivo experiments demonstrate that taurine treatment significantly enhances mitophagy, reduces oxidative stress, delays cell senescence, and promotes the removal of damaged mitochondria in nucleus pulposus cells (NPC). Additionally, taurine-mediated activation of the PINK1/Parkin pathway leads to improved mitochondrial homeostasis and slows the progression of disc degeneration. These findings provide new insights into the protective effects of taurine and highlight its potential as a therapeutic agent for IDD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Biochem Biophys Res Commun
/
Biochem. biophys. res. commun
/
Biochemical and biophysical research communications
Year:
2024
Document type:
Article
Country of publication:
Estados Unidos