Electrophysiological predictors of early response to antidepressants in major depressive disorder.
J Affect Disord
; 365: 509-517, 2024 Nov 15.
Article
in En
| MEDLINE
| ID: mdl-39187184
ABSTRACT
BACKGROUND:
Psychomotor retardation (PMR) is a core feature of major depressive disorder (MDD), which is characterized by abnormalities in motor control and cognitive processes. PMR in MDD can predict a poor antidepressant response, suggesting that PMR may serve as a marker of the antidepressant response. However, the neuropathological relationship between treatment outcomes and PMR remains uncertain. Thus, this study examined electrophysiological biomarkers associated with poor antidepressant response in MDD.METHODS:
A total of 142 subjects were enrolled in this study, including 49 healthy controls (HCs) and 93 MDD patients. All participants performed a simple right-hand visuomotor task during magnetoencephalography (MEG) scanning. Patients who exhibited at least a 50 % reduction in disorder severity at the endpoint (>2 weeks) were considered to be responders. Motor-related beta desynchronization (MRBD) and inter- and intra-hemispheric functional connectivity were measured in the bilateral motor network.RESULTS:
An increased MRBD and decreased inter- and intra-hemispheric functional connectivity in the motor network during movement were observed in non-responders, relative to responders and HCs. This dysregulation predicted the potential antidepressant response.CONCLUSION:
Abnormal local activity and functional connectivity in the motor network indicate poor psychomotor function, which might cause insensitivity to antidepressant treatment. This could be regarded as a potential neural mechanism for the prediction of a patient's treatment response.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Magnetoencephalography
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Depressive Disorder, Major
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Antidepressive Agents
Limits:
Adult
/
Female
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Humans
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Male
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Middle aged
Language:
En
Journal:
J Affect Disord
/
J. affect. disord
/
Journal of affective disorders
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Países Bajos