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A Fluorescent Lateral Flow Immunoassay for the Detection of Skeletal Muscle Troponin I in Serum for Muscle Injury Monitoring at the Point of Care.
Tang, Deding; Wu, Shuang; Kong, Mengqi; Liu, Zhaonan; Li, Zonghao; Han, Ying; Gong, Yan; Hu, Jie.
Affiliation
  • Tang D; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
  • Wu S; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, China.
  • Kong M; Public Teaching Department, Maanshan Teacher's College, Maanshan 243041, China.
  • Liu Z; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
  • Li Z; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, China.
  • Han Y; The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an 710049, China.
  • Gong Y; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, Xi'an 710049, China.
  • Hu J; Suzhou Diyinan Biotech Company, Suzhou 215129, China.
Biosensors (Basel) ; 14(8)2024 Aug 08.
Article in En | MEDLINE | ID: mdl-39194610
ABSTRACT
Exercise-induced muscle injury is one of the most common types of sports injuries. Skeletal muscle troponin I (skTnI) serves as an ideal biomarker in assessing such injuries, facilitating timely detection and evaluation. In this study, we develop a fluorescent sandwich lateral flow immunoassay (LFIA) combined with a desktop analyzer for rapid detection of skTnI. Through optimizing the reaction system, the assay achieves a satisfying detection performance, reaching a limit of detection (LOD) of 0.5 ng/mL with a turnaround time of 15 min. The proposed detection platform offers portability, ease of use, and high sensitivity, which facilitates the monitoring of exercise-induced muscle injuries at the point of care. This feature is particularly advantageous for end users, enabling timely detection of sports-related injuries and ultimately enhancing prognosis and sports life.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Point-of-Care Systems / Troponin I Limits: Humans Language: En Journal: Biosensors (Basel) Year: 2024 Document type: Article Affiliation country: China Country of publication: Suiza
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Point-of-Care Systems / Troponin I Limits: Humans Language: En Journal: Biosensors (Basel) Year: 2024 Document type: Article Affiliation country: China Country of publication: Suiza