Multimodal Deep Learning Improves Recurrence Risk Prediction in Pediatric Low-Grade Gliomas.
Neuro Oncol
; 2024 Aug 30.
Article
in En
| MEDLINE
| ID: mdl-39211987
ABSTRACT
BACKGROUND:
Postoperative recurrence risk for pediatric low-grade gliomas (pLGGs) is challenging to predict by conventional clinical, radiographic, and genomic factors. We investigated if deep learning of MRI tumor features could improve postoperative pLGG risk stratification.METHODS:
We used pre-trained deep learning (DL) tool designed for pLGG segmentation to extract pLGG imaging features from preoperative T2-weighted MRI from patients who underwent surgery (DL-MRI features). Patients were pooled from two institutions Dana Farber/Boston Children's Hospital (DF/BCH) and the Children's Brain Tumor Network (CBTN). We trained three DL logistic hazard models to predict postoperative event-free survival (EFS) probabilities with 1) clinical features, 2) DL-MRI features, and 3) multimodal (clinical and DL-MRI features). We evaluated the models with a time-dependent Concordance Index (Ctd) and risk group stratification with Kaplan Meier plots and log-rank tests. We developed an automated pipeline integrating pLGG segmentation and EFS prediction with the best model.RESULTS:
Of the 396 patients analyzed (median follow-up 85 months, range 1.5-329 months), 214 (54%) underwent gross total resection and 110 (28%) recurred. The multimodal model improved EFS prediction compared to the DL-MRI and clinical models (Ctd 0.85 (95% CI 0.81-0.93), 0.79 (95% CI 0.70-0.88), and 0.72 (95% CI 0.57-0.77), respectively). The multimodal model improved risk-group stratification (3-year EFS for predicted high-risk 31% versus low-risk 92%, p<0.0001).CONCLUSIONS:
DL extracts imaging features that can inform postoperative recurrence prediction for pLGG. Multimodal DL improves postoperative risk stratification for pLGG and may guide postoperative decision-making. Larger, multicenter training data may be needed to improve model generalizability.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Neuro Oncol
Journal subject:
NEOPLASIAS
/
NEUROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos
Country of publication:
Reino Unido