An Overview of the Analytical Methods for Products based on Clindamycin and Eco-efficiency Perspectives.
Curr Pharm Des
; 2024 Aug 29.
Article
in En
| MEDLINE
| ID: mdl-39219122
ABSTRACT
BACKGROUND:
Clindamycin (CLIN), an antibiotic sold in the form of capsules, injectable solution, gel, and lotion, is easily soluble in water and ethanol. However, it lacks eco-efficient methods for evaluating pharmaceutical products. OBJECTIVE ANDMETHOD:
The objective of this review is to provide an overview of the analytical methods present both in the literature and in official compendia for evaluating pharmaceutical matrices based on CLIN in the context of Green Analytical Chemistry (GAC).RESULTS:
Firstly, microbiological methods for evaluating the potency of CLIN final products were not found, which already shows the need to develop new methods. Among the methods found, which are all physicalchemical, the most used method is HPLC (71%) followed by UV-Vis (14%). Among the targets of the methods, capsules and raw materials were the most studied (33% each). Among the choices of analytical conditions for the methods, acetonitrile is the preferred solvent (27.7%), even though CLIN is easily soluble in ethanol.CONCLUSION:
Thus, the gap in eco-friendly and sustainable analytical methods is a reality and an opportunity for analytical development centers to provide means for evaluating the quality of CLIN-based products.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Curr Pharm Des
/
Curr. pharm. des
/
Current pharmaceutical design
Journal subject:
FARMACIA
Year:
2024
Document type:
Article
Affiliation country:
Brasil
Country of publication:
Emiratos Árabes Unidos