Preparation and characterization of mussel-inspired chitosan/polydopamine films and their feasibility for oral mucosa application.
Int J Biol Macromol
; : 135179, 2024 Sep 03.
Article
in En
| MEDLINE
| ID: mdl-39236950
ABSTRACT
Oral mucosal lesions (OML), which represent a major public health issue worldwide, include any pathological changes in the oral mucosa, such as ulcers, pigmentation, and swelling. Due to its humid and dynamic complex environment, designing oral mucosal preparations poses significant challenges. Drawing inspiration from mussels, this study employed an eco-friendly one-pot strategy for the preparation of chitosan/polydopamine (CS/PDA) films. We demonstrated that CS-induced polymerization of dopamine monomers under acidic conditions, which might be attributed to the large number of hydrogen bonding sites of CS chains. PDA markedly enhances properties of the CS film and exhibits concentration dependence. At the concentration of 1â¯wt% PDA, the lap-shear strength and tensile strength of CS/PDA films reached 5.01⯱â¯0.24 kpa and 4.20⯱â¯0.78 kpa, respectively, indicating that the mucosal adhesion ability was significantly improved. In comparison with the single CS film, the swelling rate of CS/PDA film decreased by about 30â¯%. Rheological results also showed that the storage modulus returned to 93â¯% after cyclic large strain, while the single CS film only recovered to 73â¯%. Moreover, these films demonstrated good biocompatibility and enhanced oral ulcer healing in rats, providing a new and practical option for the local treatment of OML.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Int J Biol Macromol
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Países Bajos