Aggressive low-density lipoprotein (LDL) lowering for primary prevention: still an elusive goal.
Lipids Health Dis
; 23(1): 285, 2024 Sep 06.
Article
in En
| MEDLINE
| ID: mdl-39243037
ABSTRACT
Cardiovascular disease (CVD) is the leading cause of mortality globally. Low-density lipoprotein (LDL) plays an important role in CVD pathophysiology. Research has shown the safety and efficacy of keeping LDL at very low levels for CVD prevention. Therefore, experts recommend intense LDL-lowering approaches starting at young ages, promoting the mantras "the lower, the better" and "the earlier, the better." This commentary discusses the challenges regarding applying aggressive LDL-lowering approaches in the general population, including pharmacological efficacy and side effects, the cost-effectiveness of interventions, and patient adherence to treatment regimens.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Primary Prevention
/
Cardiovascular Diseases
/
Lipoproteins, LDL
/
Cholesterol, LDL
Limits:
Humans
Language:
En
Journal:
Lipids Health Dis
/
Lipids health dis. (Online)
/
Lipids in health and disease (Online)
Journal subject:
BIOQUIMICA
/
METABOLISMO
Year:
2024
Document type:
Article
Affiliation country:
Irán
Country of publication:
Reino Unido