First hip hemiarthroplasty in a Göttingen Minipig; surgical and post-mortem protocol.
J Orthop Surg Res
; 19(1): 549, 2024 Sep 06.
Article
in En
| MEDLINE
| ID: mdl-39243099
ABSTRACT
BACKGROUND:
Prosthetic joint infections (PJI) are recalcitrant, hard-to-treat infections and severe complications of joint arthroplasty. Therefore, there is a need to develop new effective treatment strategies, and animal models of high clinical relevance are needed. This study aimed to develop a detailed surgical protocol for hip hemiarthroplasty in Göttingen minipigs and a thorough post-mortem sampling protocol to pave the way for creating a minipig PJI model.METHODS:
Three adult female Göttingen minipigs underwent surgery with insertion of a hip hemiarthroplasty, using the anterior approach to the hip joint. After surgery the minipigs were followed closely with daily clinical evaluation and gait scoring. Comprehensive post-mortem analyses were performed with evaluation of macroscopic lesions, microbiology, synovial fluid analysis and histology.RESULTS:
The study resulted in the first Göttingen minipig with hip hemiarthroplasty and identified several points of awareness when inserting a hip prosthesis in minipigs, especially the high risk of joint dislocation. A spontaneous PJI occurred in one of the minipigs, revealing an impaired ability of the immune cells to reach the bacteria at the bone-prosthesis interface.CONCLUSION:
The present study provides a detailed description of surgical technique and post-mortem sampling and validates the suitability of the hip hemiarthroplasty minipig model for future experimental modeling of PJI.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Swine, Miniature
/
Prosthesis-Related Infections
/
Arthroplasty, Replacement, Hip
/
Hemiarthroplasty
Limits:
Animals
Language:
En
Journal:
J Orthop Surg Res
Year:
2024
Document type:
Article
Affiliation country:
Dinamarca
Country of publication:
Reino Unido