Biosynthesis of positively charged bacterial cellulose hydrogel with antibacterial and anti-inflammatory function for efficient wound healing.
Int J Biol Macromol
; : 135263, 2024 Sep 05.
Article
in En
| MEDLINE
| ID: mdl-39244128
ABSTRACT
In bacterial cellulose (BC)-based living materials, the effective and permanent incorporation of bactericidal agents into BC remains a persistent challenge. In this study, midazole quaternary ammonium salt was grafted onto a dispersion of bacterial cellulose, which was subsequently directly added to the fermentation medium of BC-producing bacteria to obtain BC-based hydrogel materials (BC/BC-[PQVI]Br) with inherent antibacterial properties. The BC/BC-[PQVI]Br hydrogel prepared in this study exhibits favorable tensile properties, with a maximum tensile stress of 970â¯KPa and water retention for up to 6â¯h. Moreover, it demonstrates acceptable antibacterial activity against S. aureus (93â¯%) and E. coli (71â¯%), respectively. Additionally, the hydrogel displays a high cell survival rate of 98â¯% after contact with NIH3T3 cells, indicating its non-cytotoxic nature. Furthermore, the mouse wound experiment confirms the excellent wound healing effect of the hydrogel. This research presents an innovative approach towards developing environmentally friendly active wound dressings with microbial-derived antibacterial functionality.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Int J Biol Macromol
Year:
2024
Document type:
Article
Affiliation country:
China
Country of publication:
Países Bajos