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Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study.
Thakral, Abhinav; Lee, John Jw; Hou, Tianzhichao; Hueniken, Katrina; Dudding, Tom; Gormley, Mark; Virani, Shama; Olshan, Andrew; Diergaarde, Brenda; Ness, Andrew R; Waterboer, Tim; Smith-Byrne, Karl; Brennan, Paul; Hayes, D Neil; Sanderson, Eleanor; Brown, M Catherine; Huang, Sophie; Bratman, Scott V; Spreafico, Anna; De Almeida, John; Davies, Joel C; Bierut, Laura; Macfarlane, Gary J; Lagiou, Pagona; Lagiou, Areti; Polesel, Jerry; Agudo, Antonio; Alemany, Laia; Ahrens, Wolfgang; Healy, Claire M; Conway, David I; Nygard, Mari; Canova, Cristina; Holcatova, Ivana; Richiardi, Lorenzo; Znaor, Ariana; Goldstein, David P; Hung, Rayjean J; Xu, Wei; Liu, Geoffrey; Espin-Garcia, Osvaldo.
Affiliation
  • Thakral A; Department of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Lee JJ; Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada. Jongwook.lee@utoronto.ca.
  • Hou T; Department of Otolaryngology - Head and Neck Surgery, Sinai Health System, Toronto, Ontario, Canada. Jongwook.lee@utoronto.ca.
  • Hueniken K; Department of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Dudding T; Department of Biostatistics, Princess Margaret Cancer Centre-University Health Network, University of Toronto, Toronto, Ontario, Canada.
  • Gormley M; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1TL, UK.
  • Virani S; University of Bristol Dental School, 1 Trinity Walk, Avon Street, Bristol, BS2 0PT, UK.
  • Olshan A; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1TL, UK.
  • Diergaarde B; University of Bristol Dental School, 1 Trinity Walk, Avon Street, Bristol, BS2 0PT, UK.
  • Ness AR; Genomic Epidemiology Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Waterboer T; Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
  • Smith-Byrne K; Department of Human Genetics, School of Public Health, University of Pittsburgh, and UPMC Hillman Cancer Center, Pittsburgh, PA, 15260, USA.
  • Brennan P; University Hospitals Bristol and Weston NHS Foundation Trust National Institute for Health Research Bristol Biomedical Research Centre, University of Bristol, Bristol, BS1 3NU, UK.
  • Hayes DN; Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Sanderson E; Genomic Epidemiology Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Brown MC; Genomic Epidemiology Branch, International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Huang S; Division of Medical Oncology and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA.
  • Bratman SV; MRC Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1TL, UK.
  • Spreafico A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • De Almeida J; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Davies JC; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
  • Bierut L; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Macfarlane GJ; Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada.
  • Lagiou P; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Lagiou A; Division of Medical Oncology and Hematology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Polesel J; Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Agudo A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada.
  • Alemany L; Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Ahrens W; Department of Otolaryngology - Head and Neck Surgery, Sinai Health System, Toronto, Ontario, Canada.
  • Healy CM; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
  • Conway DI; Epidemiology Group, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
  • Nygard M; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, National and Kapodistrian, University of Athens, Goudi, Greece.
  • Canova C; Department of Public and Community Health, School of Public Health, University of West Attica, Athens, Greece.
  • Holcatova I; Unit of Cancer Epidemiology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
  • Richiardi L; Cancer Epidemiology Research Programme, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Madrid, Spain.
  • Znaor A; Cancer Epidemiology Research Programme, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Madrid, Spain.
  • Goldstein DP; Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany; Department of Mathematics and Computer Science, University of Bremen, Bremen, Germany.
  • Hung RJ; Department of Oral and Maxillofacial Surgery, Oral Medicine and Oral Pathology, Dublin Dental University Hospital, Trinity College Dublin, Dublin, Ireland.
  • Xu W; School of Medicine, Dentistry, and Nursing, University of Glasgow, Glasgow, UK.
  • Liu G; Department of Research, Cancer Registry of Norway, Norwegian Institute of Public Health, Oslo, Norway.
  • Espin-Garcia O; University of Padua, Padova, Italy.
Nat Commun ; 15(1): 7835, 2024 Sep 07.
Article in En | MEDLINE | ID: mdl-39244563
ABSTRACT
HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are recognized as distinct entities. There remains uncertainty surrounding the causal effects of smoking and alcohol on the development of these two cancer types. Here we perform multivariable Mendelian randomization (MR) to evaluate the causal effects of smoking and alcohol on the risk of HPV-positive and HPV-negative HNSCC in 3431 cases and 3469 controls. Lifetime smoking exposure, as measured by the Comprehensive Smoking Index (CSI), is associated with increased risk of both HPV-negative HNSCC (OR = 3.03, 95%CI1.75-5.24, P = 7.00E-05) and HPV-positive HNSCC (OR = 2.73, 95%CI1.39-5.36, P = 0.003). Drinks Per Week is also linked with increased risk of both HPV-negative HNSCC (OR = 7.72, 95%CI3.63-16.4, P = 1.00E-07) and HPV-positive HNSCC (OR = 2.66, 95%CI1.06-6.68, P = 0.038). Smoking and alcohol independently increase the risk of both HPV-positive and HPV-negative HNSCC. These findings have important implications for understanding the modifying risk factors between HNSCC subtypes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alcohol Drinking / Smoking / Papillomavirus Infections / Mendelian Randomization Analysis / Squamous Cell Carcinoma of Head and Neck / Head and Neck Neoplasms Limits: Female / Humans / Male / Middle aged Language: En Journal: Nat Commun / Nature communications Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country: Canadá Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alcohol Drinking / Smoking / Papillomavirus Infections / Mendelian Randomization Analysis / Squamous Cell Carcinoma of Head and Neck / Head and Neck Neoplasms Limits: Female / Humans / Male / Middle aged Language: En Journal: Nat Commun / Nature communications Journal subject: BIOLOGIA / CIENCIA Year: 2024 Document type: Article Affiliation country: Canadá Country of publication: Reino Unido