Methemoglobin in critically ill septic patients.
Biomark Med
; : 1-8, 2024 Sep 13.
Article
in En
| MEDLINE
| ID: mdl-39269846
ABSTRACT
Aim:
Higher nitric oxide (NO) levels correlate with adverse sepsis outcomes but are challenging to measure. Methemoglobin (MetHb), a measurable product of NO, has not been utilized for risk stratification.Methodology:
All patients with sepsis admitted to the intensive care unit (ICU) that had at least one MetHb measurement within 24 h of ICU admission were retrospectively analyzed. We assessed the epidemiology and associations of MetHb with hospital mortality.Results:
Among 7724 patients, 1046 qualified. Those with MetHb ≥1.6% showed significantly higher mortality and fewer days alive outside the hospital by day 28. MetHb levels ≥1.6% independently predicted increased 28-day mortality.Conclusion:
Our findings suggest MetHb, easily obtainable from arterial blood gases, can significantly enhance sepsis risk stratification.
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Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Biomark Med
Journal subject:
BIOQUIMICA
/
MEDICINA
Year:
2024
Document type:
Article
Affiliation country:
Australia
Country of publication:
Reino Unido