Benchmarking deep learning-based low-dose CT image denoising algorithms.

ABSTRACT

BACKGROUND: Long-lasting efforts have been made to reduce radiation dose and thus the potential radiation risk to the patient for computed tomography (CT) acquisitions without severe deterioration of image quality. To this end, various techniques have been employed over the years including iterative reconstruction methods and noise reduction algorithms. PURPOSE: Recently, deep learning-based methods for noise reduction became increasingly popular and a multitude of papers claim ever improving performance both quantitatively and qualitatively. However, the lack of a standardized benchmark setup and inconsistencies in experimental design across studies hinder the verifiability and reproducibility of reported results. METHODS: In this study, we propose a benchmark setup to overcome those flaws and improve reproducibility and verifiability of experimental results in the field. We perform a comprehensive and fair evaluation of several state-of-the-art methods using this standardized setup. RESULTS: Our evaluation reveals that most deep learning-based methods show statistically similar performance, and improvements over the past years have been marginal at best. CONCLUSIONS: This study highlights the need for a more rigorous and fair evaluation of novel deep learning-based methods for low-dose CT image denoising. Our benchmark setup is a first and important step towards this direction and can be used by future researchers to evaluate their algorithms.