Interaction between genetic risk score and dietary fat intake on lipid-related traits in Brazilian young adults.

ABSTRACT

The occurrence of dyslipidaemia, which is an established risk factor for cardiovascular diseases, has been attributed to multiple factors including genetic and environmental factors. We used a genetic risk score (GRS) to assess the interactions between genetic variants and dietary factors on lipid-related traits in a cross-sectional study of 190 Brazilians (mean age 21 ± 2 years). Dietary intake was assessed by a trained nutritionist using three 24-h dietary recalls. The high GRS was significantly associated with increased concentration of TAG (beta = 0·10 mg/dl, 95 % CI 0·05-0·16; P < 0·001), LDL-cholesterol (beta = 0·07 mg/dl, 95 % CI 0·04, 0·11; P < 0·0001), total cholesterol (beta = 0·05 mg/dl, 95 % CI 0·03, 0·07; P < 0·0001) and the ratio of TAG to HDL-cholesterol (beta = 0·09 mg/dl, 95 % CI 0·03, 0·15; P = 0·002). Significant interactions were found between the high GRS and total fat intake on TAGHDL-cholesterol ratio (Pinteraction = 0·03) and between the high GRS and SFA intake on TAGHDL-cholesterol ratio (Pinteraction = 0·03). A high intake of total fat (>31·5 % of energy) and SFA (>8·6 % of energy) was associated with higher TAGHDL-cholesterol ratio in individuals with the high GRS (beta = 0·14, 95 % CI 0·06, 0·23; P < 0·001 for total fat intake; beta = 0·13, 95 % CI 0·05, 0·22; P = 0·003 for SFA intake). Our study provides evidence that the genetic risk of high TAGHDL-cholesterol ratio might be modulated by dietary fat intake in Brazilians, and these individuals might benefit from limiting their intake of total fat and SFA.