Ameliorative Effect of Herbal Medicine in the Management of Hepatotoxicity.
Endocr Metab Immune Disord Drug Targets
; 2024 Sep 23.
Article
in En
| MEDLINE
| ID: mdl-39318011
ABSTRACT
Reactive oxygen species production, inflammation, an elevated serum profile, mitochondrial dysfunction, and up-regulation of proapoptotic mediators are the main mechanisms underlying chemotherapy-related hepatotoxicity, which results in hepatocyte disorders such as hepatitis, steatohepatitis, and fibrosis. The article aims to examine a prospective herbal remedy and its bioactive ingredients in terms of its antioxidant, anti-inflammatory, and anti-apoptotic capabilities, which offer superior protection against liver damage during chemotherapy administration. Plants including Silybum marianun, Nelumbo nucifera, Phyllanthus amarus, Plumbago zeylanica, Glycyrrhiza glabra, Citrus limon, and Nigella sativa may have hepatoprotective properties, according to the author. Last but not least, this will give aspiring scientists new knowledge for natural-based development in mitigating liver damage caused by chemotherapy medications.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Endocr Metab Immune Disord Drug Targets
Journal subject:
ALERGIA E IMUNOLOGIA
/
ENDOCRINOLOGIA
/
METABOLISMO
/
TERAPIA POR MEDICAMENTOS
Year:
2024
Document type:
Article
Affiliation country:
India
Country of publication:
Emiratos Árabes Unidos