Focal glomerulosclerosis associated with Charcot-Marie-Tooth disease.
Nephron
; 40(3): 357-61, 1985.
Article
in En
| MEDLINE
| ID: mdl-4010852
This report describes a new case of the rare association of focal glomerulosclerosis with a peroneal muscular atrophy of the Charcot-Marie-Tooth type. The young patient was admitted with a nephrotic syndrome. A terminal renal failure rapidly developed. Numerous chronic nephropathies were known in the patient's family. The ultrastructural study of the renal biopsy revealed a focal fusion of the epithelial foot processes, thickened and pleated mesangial basal laminae, vacuolated podocytes and small intranuclear clear inclusions. The Charcot-Marie-Tooth disease was of the hypertrophic type. According to a review of the literature and to further information concerning the follow-up of the 5 previously reported cases, the prognosis of the nephropathy is guarded with progression to end-stage renal disease in a few years. This case represents the 6th reported case of focal glomerulosclerosis associated with Charcot-Marie-Tooth disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glomerulosclerosis, Focal Segmental
/
Muscular Atrophy
/
Charcot-Marie-Tooth Disease
/
Glomerulonephritis
Type of study:
Prognostic_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Humans
/
Male
Language:
En
Journal:
Nephron
Year:
1985
Document type:
Article
Country of publication:
Suiza