Clinical pharmacology of methicillin in neonates.
J Pediatr
; 90(6): 1005-8, 1977 Jun.
Article
in En
| MEDLINE
| ID: mdl-558302
ABSTRACT
The pharmacokinetic properties of methicillin were investigated in 59 newborn infants. Concentrations of methicillin in serum were approximately 58 and 80 microng/ml at one hour after 25 and 50 mg/kg doses, respectively. The average serum half-life values ranged from one to three hours and were inversely correlated with birth weight and chronologic age. The half-life values, volumes of distribution, and plasma clearances of methicillin are shown in relationship to gestational age and chronologic age. A dosage of 25 mg/kg is recommended for therapy of most neonatal staphylococcal diseases; the frequency of administration is altered on the basis of birth weight and chronologic age.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Methicillin
Limits:
Female
/
Humans
/
Newborn
/
Pregnancy
Language:
En
Journal:
J Pediatr
Year:
1977
Document type:
Article