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Metabolic fate of administered 1,25-dihydroxycholecalciferol in controls and in patients with hypoparathyroidism.
Lancet ; 1(7971): 1203-6, 1976 Jun 05.
Article in En | MEDLINE | ID: mdl-58255
In four healthy controls and three patients with hypoparathyroidism serum-1,25-dihydroxycholecalciferol (1,25-D.H.C.C.) concentrations, after oral or intravenous administration, declined biphasically with a rapid-phase half-time of about 14 hours. Repeated oral doses of 1 mug 1,25-D.H.C.C. (2-4 nmol) produced serum concentrations well below the assayed normal range but were nevertheless effective in raising serum-calcium. It is suggested that orally administered 1,25-D.H.C.C. acts directly on the intestinal mucosal-cell nucleus to promote calcium absorption. 1,25-D.H.C.C. is more rapidly eliminated from the body than vitamin D, and it is predicted that any hypercalcaemia caused by 1,25-D.H.C.C. therapy should be of relatively short duration.
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Collection: 01-internacional Database: MEDLINE Main subject: Dihydroxycholecalciferols / Hydroxycholecalciferols / Hypoparathyroidism Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Lancet Year: 1976 Document type: Article Country of publication: Reino Unido
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Collection: 01-internacional Database: MEDLINE Main subject: Dihydroxycholecalciferols / Hydroxycholecalciferols / Hypoparathyroidism Type of study: Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Lancet Year: 1976 Document type: Article Country of publication: Reino Unido