Ceftriaxone pharmacokinetics in newborn infants.
Antimicrob Agents Chemother
; 23(2): 341-3, 1983 Feb.
Article
in En
| MEDLINE
| ID: mdl-6301369
ABSTRACT
Ceftriaxone pharmacokinetics were determined in 40 newborn infants who were 1 to 45 days of age. Mean peak plasma concentrations of 136 to 173 micrograms/ml were observed at the completion of a 15-min intravenous infusion of 50 mg of ceftriaxone per kg. Mean half-life values were 5.2 to 8.4 h, and mean plasma clearances were 0.7 to 1.8 ml/min. Rectal swab cultures from 14 of 16 infants had either reduced numbers of aerobic and anaerobic bacteria or no growth during therapy. A once-daily dosage schedule is suggested for ceftriaxone therapy in newborn infants.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cefotaxime
/
Infant, Newborn, Diseases
/
Anti-Bacterial Agents
Limits:
Humans
/
Infant
/
Newborn
Language:
En
Journal:
Antimicrob Agents Chemother
Year:
1983
Document type:
Article