Changes of arachidonic acid and n-3 polyunsaturated fatty acids of phospholipid classes in liver, plasma and platelets during dietary fat manipulation.
Biochim Biophys Acta
; 793(3): 441-7, 1984 May 11.
Article
in En
| MEDLINE
| ID: mdl-6424720
ABSTRACT
When rats adapted to a fat-free diet were fed a corn oil diet, endogenous n-9 eicosatrienoic acid (the major polyunsaturated fatty acid) at the C-2 position of both phosphatidylcholine and phosphatidylethanolamine was quickly substituted by arachidonic acid in liver, plasma and platelets. Comparably, under a fish oil diet, the n-9 was quickly substituted by n-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid). In both cases the n-9 almost disappeared in 6 days. On the other hand, when the dietary process was reversed, arachidonic acid in both the phospholipid classes (especially in phosphatidylcholine) decreased more slowly than the n-3 in the platelets and the liver mitochondria and microsomes. In platelets, even in linoleate-deficient rats, much arachidonic acid remained. However, arachidonic acid decreased similarly to the n-3 in the plasma. These results may reveal the physiological significance of arachidonic acid in membrane phospholipids, the replacement of arachidonic acid by the n-3 and the limitation of the replacement.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Phospholipids
/
Blood Platelets
/
Dietary Fats
/
Arachidonic Acids
/
Fatty Acids, Unsaturated
/
Liver
Limits:
Animals
Language:
En
Journal:
Biochim Biophys Acta
Year:
1984
Document type:
Article