Polycationic polypeptides: a possible model for the penetration-enhancing factor in the invasion of host cells by Toxoplasma gondii.
J Gen Microbiol
; 130(4): 927-33, 1984 Apr.
Article
in En
| MEDLINE
| ID: mdl-6736923
ABSTRACT
The effect of polycationic polypeptides (polylysine, polyarginine and polyhistidine) on the invasion of mammalian cells and plant protoplasts by Toxoplasma gondii was studied. In JM cells, a human lymphoblastoid cell line with T cell characteristics, all polycationic polypeptides used increased the invasion rate in a concentration-dependent manner. This effect and the morphological changes revealed by electron microscopy resembled the action of the penetration-enhancing factor previously described by E. Lycke and co-workers. Plant protoplasts of Catharanthus roseus, which are resistant to T. gondii invasion, showed the same morphological changes in the presence of polycationic polypeptides as observed for JM cells, but were not invaded.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Polylysine
/
Toxoplasma
/
Histidine
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
J Gen Microbiol
Year:
1984
Document type:
Article